CYT997
货号：
18395-50mg 基本售价：
13230.0 元 规格：
50 mg
产品信息
概述| 货号 | 18395-50mg |
| 描述 | CYT997 is an orally available inhibitor of microtubule polymerization (IC50 = ~3 µM) that blocks cell cycling at the G2-M phase, which leads to cell death.1 It is cytotoxic to a range of cancer cell lines (IC50s = 9-101 nM) and demonstrates antivascular activity in tumors both in vitroandin vivo.1,2 CYT997 is being examined in clinical trials for efficacy against advanced solid tumors.3 |
| 别名 | Lexibulin; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Burns, C.J.,Fantino, E.,Philips, I.D., et al. CYT997: A novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Molecular Cancer Therapeutics 8(11), 3036-3045 (2009).
2.Burns, C.J.,Fantino, E.,Powell, A.K., et al. The microtubule depolymerizing agent CYT997 causes extensive ablation of tumor vasculature in vivo. Journal of Pharmacology and Experimental Therapeutics 339(3), 799-806 (2011).
3.Lickliter, J.D.,Francesconi, A.B.,Smith, G., et al. Phase I trial of CYT997, a novel cytotoxic and vascular-disrupting agent. British Journal of Cancer 103(5), 597-606 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 434.5 |
| 分子式 | C24H30N6O2 |
| CAS号 | 917111-44-5 |
| 稳定性 | ≥ 2 years |
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