Danusertib
货号：
18387-50mg 基本售价：
13230.0 元 规格：
50 mg
产品信息
概述| 货号 | 18387-50mg |
| 描述 | Danusertib is a pan-Aurora kinase inhibitor (IC50s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, TrkA and FGFR1 (IC50s = 25, 31, 31, and 47 nM, respectively).1 It exhibits anti-proliferative and pro-apoptotic activity against a panel of cancer cells in vitro, including those expressing wild type and mutant Bcr-Abl.1,2 Danusertib is effective against diverse xenografts in mice, including those containing mutant Bcr-Abl that are resistant to imatinib (Item No. 13139).1,2,3 |
| 别名 | PHA-739358; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Carpinelli, P.,Ceruti, R.,Giorgini, M.L., et al. PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer. Mol. Cancer Ther. 6(12 Pt 1), 3158-3153 (2007).
2.Gontarewicz, A.,Balabanov, S.,Keller, G., et al. Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I. Blood 111(8), 4355-4364 (2008).
3.Moore, A.S.,Blagg, J.,Linardopoulos, S., et al. Aurora kinase inhibitors: Novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias. Leukemia 24(4), 671-678 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 474.6 |
| 分子式 | C26H30N6O3 |
| CAS号 | 827318-97-8 |
| 稳定性 | ≥ 2 years |
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