| 货号 | 17753-5mg |
| 描述 | Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals. Generated by a family of diadenylate cyclases, c-di-AMP can impact bacterial cell growth, cell wall homeostasis, pathogenicity, and other cellular functions.1,2,3 Bacteria-derived cyclic dinucleotides, including c-di-AMP, trigger the expression of interferon genes in mammalian cells.4,5 |
| 别名 | c-di-AMP;Cyclic di-Adenosine monophosphate;3,5-Cyclic diadenylic acid;Cyclic diadenylate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Schaap, P. Cyclic di-nucleotide signaling enters the eukaryote domain. IUBMB Life 65(11), 897-903 (2013). 2.Luo, Y., and Helmann, J.D. Analysis of the role of Bacillus subtilis σM in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis. Molecular Microbiology 83(3), 623-639 (2012). 3.Corrigan, R.M., and Gründling, A. Cyclic di-AMP: Another second messenger enters the fray. Nature Reviews.Microbiology 11, 513-524 (2013). 4.Konno, H.,Konno, K., and Barber, G.N. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155(3), 688-698 (2013). 5.Gao, P.,Ascano, M.,Zillinger, T., et al. Structure-function analysis of STING activation by c[G(2,5)pA(3,5)p] and targeting by antiviral DMXAA. Cell 154(4), 748-762 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 658.4 |
| 分子式 | C20H24N10O12P2 |
| CAS号 | 54447-84-6 |
| 稳定性 | ≥ 2 years |
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