| 货号 | 10012562-25mg |
| 描述 | Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated, long-chain fatty acids to monounsaturated fatty acids. The SCD1 gene is thought to play a key role in lipid homeostasis and body weight regulation.1,2,3 Thus, modulating SCD1 activity pharmacologically may be a useful tool for regulating type 2 diabetes, dyslipidemia, and obesity. CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.4 This compound inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells with IC50 values of 7.9 and 6.8 nM, respectively, when heptadecanoic acid and palmitic acid are used as the substrate.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cohen, P.,Miyazaki, M.,Socci, N.D., et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297, 240-243 (2002). 2.Dobrzyn, P.,Sampath, H.,Dobrzyn, A., et al. Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart. American Journal of Physiology.Endocrinology and Metabolism 294, E357-E364 (2008). 3.Miyazaki, M.,Flowers, M.T.,Sampath, H., et al. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metabolism 6, 484-496 (2007). 4.Liu, G.,Lynch, J.K.,Freeman, J., et al. Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors. Journal of Medicinal Chemistry 50, 3086-3100 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 389.8 |
| 分子式 | C18H17ClFN5O2 |
| CAS号 | 944808-88-2 |
| 稳定性 | ≥ 2 years |
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