| 货号 | 13181-50mg |
| 描述 | Phospholipase A2(PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis.1 Three primary types of PLA2 exist: secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2).2 Of these three enzymes, cPLA2 is the rate-limiting stimulus for release of arachidonic acid whereas sPLA2 amplifies the action of cPLA2 and regulates phagocytosis and foam cell formation.3 CAY10590, a simple amide based on (R)-γ-norleucine, is a potent and selective inhibitor of sPLA2. It exhibits 95% inhibition (XI(50) = 0.003) of sPLA2 at 0.091 mole fraction without affecting the activities of cPLA2 or iPLA2.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dennis, E.A. Phospholipases. Enzymes XVI, 307-353 (1983). 2.Dennis, E.A. Diversity of group types, regulation, and function of phospholipase A2. The Journal of Biological Chemisty 269, 13057-13060 (1994). 3.Balestrieri, B. and Arm, J.P. Group V sPLA2: Classical and novel functions. Biochimica et Biophysica Acta 1761, 1280-1288 (2006). 4.Antonopoulou, G.,Barbayianni, E.,Magrioti, V., et al. Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A2 enzymes. Bioorganic & Medicinal Chemistry 16, 10257-10269 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 347.5 |
| 分子式 | C21H33NO3 |
| CAS号 | 1101136-50-8 |
| 稳定性 | ≥ 2 years |
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