| 货号 | 11678-5g |
| 描述 | Aloin A is a natural bioactive anthroquinone glycoside that can be isolated from plants of the genus Aloe. The two forms of aloin, A and B, are diastereomer C-glycosides of aloe-emodin (Item No. 11677), which has potent laxative and cytotoxic properties.1,2 Studies using an undefined mixture of aloin diastereomers report that aloin has cytotoxic properties against cancer cells as well as antioxidant effects.3,4 It is absorbed after gavage in rats and reaches a peak plasma level within 1-1.5 hours after administration.5 Aloin has a bitter taste and has been studied as an agonist of bitter taste receptors.6 |
| 别名 | Barbaloin;NSC 407305; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pecere, T.,Gazzola, M.V.,Mucignat, C., et al. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Research 60(11), 2800-2804 (2000). 2.Xu, J.D.,Liu, S.,Wang, W., et al. Emodin induces chloride secretion in rat distal colon through activation of mast cells and enteric neurons. British Journal of Pharmacology 165(1), 197-207 (2012). 3.Harlev, E.,Nevo, E.,Lansky, E.P., et al. Anticancer potential of aloes: Antioxidant, antiproliferative, and immunostimulatory attributes. Planta 78(9), 843-852 (2012). 4.Liu, F.-W.,Liu, F.-C.,Wang, Y.-R., et al. Aloin Protects Skin Fibroblasts from Heat Stress-Induced Oxidative Stress Damage by Regulating the Oxidative Defense System. PLoS One 10(12), e0143528 (2015). 5.Park, M.-Y.,Kwon, H.-J., and Sung, M.-K. Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin. Nutr. Res. Pract. 2(1), 17-21 (2008). 6.Pronin, A.N.,Xu, H.,Tang, H., et al. Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Curr. Biol. 17(16), 1403-1408 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 418.4 |
| 分子式 | C21H22O9 |
| CAS号 | 1415-73-2 |
| 稳定性 | ≥ 2 years |
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