11-cis Retinal
货号：
21377-1mg 基本售价：
13174.0 元 规格：
1 mg
产品信息
概述| 货号 | 21377-1mg |
| 描述 | 11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin.1 When 11-cis retinal absorbs a photon of light, it isomerizes to form all-trans retinal (Item No. 18449) beginning the phototransduction cycle, which is the basis for mammalian vision. A G121L mutation in opsin allows 11-cis retinal to bind as a partial agonist and activate rhodopsin in the absence of light.2 In a moth model of carotenoid deficiency-induced low visual sensitivity, 11-cis retinal application to compound eyes restored visual sensitivity almost completely.3 |
| 别名 | 11-cis-Retinaldehyde;11-cis-Vitamin A aldehyde; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tradtrantip, L.,Sonawane, N.D.,Namkung, W., et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J.Med.Chem 52(20), 6447-6455 (2009).
2.Han, M.,Lou, J.,Nakanishi, K., et al. Partial agonist activity of 11-cis-retinal in rhodopsin mutants. J. Biol. Chem. 272(37), 23081-23085 (1997).
3.Bennett, R.R. and White, R.H. 11-cis retinal restores visual function in vitamin A-deficient Manduca. Vis. Neurosci. 6(5), 473-479 (1991).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥65% |
| 计算分子量 | 284.4 |
| 分子式 | C20H28O |
| CAS号 | 564-87-4 |
| 稳定性 | ≥ 6 months |
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