(+)-trans-C75
货号：
9000783-10mg 基本售价：
13132.0 元 规格：
10 mg
产品信息
概述| 货号 | 9000783-10mg |
| 描述 | C75 is stable fatty acid synthase (FAS) inhibitor that when administered in racemic form leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/obmice.1 C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway.2(+)-trans-C75 is an enantiomer of C75.3 Its biologicial activity has not been reported. |
| 别名 | (2R,3S)-C75; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Loftus, T.M.,Jaworsky, D.E.,Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379-2381 (2000).
2.Pizer, E.S.,Thupari, J.,Han, W.F., et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Research 60, 213-218 (2000).
3.Chakrabarty, K.,Forzato, C.,Nitti, P., et al. The first kinetic enzymatic resolution of methyl ester of C75. Letters in Organic Chemistry 7, 245-248 (2010).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 254.3 |
| 分子式 | C14H22O4 |
| CAS号 | 1234694-20-2 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
