| 货号 | 500431-480Solid |
| 描述 | The isoprostanes are a family of eicosanoids of non-enzymatic origin produced by the random oxidation of tissue phospholipids by oxygen radicals. At least one of the isoprostanes, 8-isoprostane (8-isoPGF2α), has biological activity and has implicated as a causative mediator and specific marker of free radical-induced damage in a variety of diseases related to oxidative stress.1,2,3,4 Cayman Chemicals STAT-8-isoprostane ELISA is a competitive assay that permits the rapid measurement of 8-isoPGF2α from biological samples, requiring only 1 hour incubation and development times for each step. This assay format is the similar to that employed in Caymans popular 8-isoprostane ELISA (Item No. 516351) with the only change being the use of an alkaline phosphatase tracer in place of an AChE tracer. While Item No. 516351 offers superior sensitivity (IC50 ~35 pg/ml), the new STAT-8-isoprostane Assay offers the convenience of a fast assay while still achieving an IC50 of 180 pg/ml and a detection limit (80% B/B0) of approximately 45 pg/ml. |
| 别名 | iPF2α-III Alkaline Phosphatase;STAT-8-Isoprostane EIA Kit;STAT-8-epi Prostaglandin F2α;STAT-8-iso Prostaglandin F2α; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Banerjee, M.,Kang, K.H.,Morrow, J.D., et al. Effects of a novel prostaglandin, 8-epi-PGF2α, in rabbit lung in situ. American Journal of Physiology 263, H660-H663 (1992). 2.Vacchiano, C.A. and Tempel, G.E. Role of nonenzymatically generated prostanoid, 8-iso-PGF2α, in pulmonary oxygen toxicity. Journal of Applied Physiology 77, 2912-2917 (1994). 3.Praticò, D.,Lawson, J.A.,Rokach, J., et al. The isoprostanes in biology and medicine. Trends in Endocrinology and Metabolism 12(6), 243-247 (2001). 4.Greco, A.,Minghetti, L. and Levi, G. Isoprostanes, novel markers of oxidative injury, help understanding the pathogenesis of neurodegenerative diseases. Neurochemical Research 25(9/10), 1357-1364 (2000). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
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