AX 048
货号：
13823-5mg 基本售价：
13132.0 元 规格：
5 mg
产品信息
概述| 货号 | 13823-5mg |
| 描述 | The group IVA phospholipase A2(PLA2), known as calcium-dependent cytosolic PLA2(cPLA2), selectively releases arachidonic acid from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes.1 AX 048 is a potent group IVA cPLA2 inhibitor that demonstrates 50% inhibition of the enzyme at a mole fraction (XI(50)) of 0.022. Pretreatment with AX 048 (ED50 = 1.2 mg/kg) dose-dependently reduces thermal hyperalgesia evoked by carrageenan injection of rat hind paw.2 At concentrations as high as 30 µM, AX 048 does not inhibit COX activity or interfere with central cannabinoid receptor signaling.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dennis, E.A. Diversity of group types, regulation, and function of phospholipase A2. The Journal of Biological Chemisty 269, 13057-13060 (1994).
2.Yaksh, T.L.,Kokotos, G.,Svensson, C.I., et al. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. Journal of Pharmacology and Experimental Therapeutics 316(1), 466-475 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 383.6 |
| 分子式 | C22H41NO4 |
| CAS号 | 873079-69-7 |
| 稳定性 | ≥ 2 years |
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