| 货号 | 4767/50 |
| 别名 | 5-(Phenylsulfonyl)-N-4-piperidinyl- |
| 供应商 | Tocris |
| 生物活性 | Secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 484.94 |
| 分子式 | C18H19F3N2 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Mooreet al (2010) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg.Med.Chem. 18 190. PMID: 19932972. Bodineet al (2009) A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 44 1063. PMID: 19254787. Mooreet al (2009) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J.Med.Chem. 52 105. PMID: 19072540. |