| 货号 | 2078/50 |
| 别名 | (RS)-1-(2-Amino-2-carboxyethyl)-3-( |
| 供应商 | Tocris |
| 生物活性 | Selective GluR5-subunit containing kainate receptor antagonist (apparent KD = 1.09 μM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Active enantiomer UBP 302 (Cat. No. 2079) available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 333.3 |
| 分子式 | C15H15N3O6 |
| 可溶性/溶解性 | Soluble to 10 mM in 1eq. NaOH with gentle warming and to 10 mM in DMSO |
| 参考文献 | Dolmanet al (2005) Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J.Med.Chem. 48 7867. PMID: 16302825. Moreet al (2004) Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology 47 46. PMID: 15165833. |