TC-G 1004 (50 MG)
货号：
4407/50 基本售价：
13077.2 元 规格：
50 mg
产品信息
概述| 货号 | 4407/50 |
| 别名 | N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl)-2-pyridinyl]-4-pyrimidinyl]acetamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent antagonist of adenosine A2A receptors; displays >100-fold selectivity for A2A over A1 receptors (Ki values are 0.44 and 85 nM respectively). Potentiates L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 421.5 |
| 分子式 | C22H27N7O2 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO |
| 参考文献 | Zhanget al (2008) Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease. J.Med.Chem. 51 7099. PMID: 18947224. |
