| 货号 | 1661/50 |
| 别名 | 3,5-Dihydro-5-methyl-N-3-pyridinylb |
| 供应商 | Tocris |
| 生物活性 | Potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2BpA2 = 8.89, human 5-HT2CpKi = 7.92). Displays > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6). Centrally active following oral administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 328.8 |
| 分子式 | C17H16N4O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 158942-04-2 |
| 参考文献 | Porraset al (2002) 5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum. Neuropsychopharmacology 26 311. PMID: 11850146. Kennettet al(1996)In vitroandin vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties. Br.J.Pharmacol. 117 427. PMID: 8821530. Forbeset al (1995) 5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity and oral activity. J.Med.Chem. 38 2524. PMID: 7629791. |