| 货号 | 4763/50 |
| 别名 | 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-am |
| 供应商 | Tocris |
| 生物活性 | Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 778.94 |
| 分子式 | C31H32N8O5 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | Rodriguezet al (20112) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat.Chem.Biol. 8 301. PMID: 22306580. Koiralaet al (2011) A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat.Chem. 3 782. PMID: 21941250. M |