| 货号 | 1581/50 |
| 别名 | (2R)-2-[[6-[(3-Chloro-4-carboxyphen |
| 供应商 | Tocris |
| 生物活性 | Cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC50 > 10,000 nM). Shown to have antiproliferative properties, mediated by p42/p44 MAPK. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 432.91 |
| 分子式 | C20H25ClN6O3 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH with gentle warming and to 100 mM in DMSO |
| CAS号 | 212844-54-7 |
| 参考文献 | Knockaertet al (2002) p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene 21 6413. PMID: 12226745. Grayet al (1999) ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 6 859. PMID: 10495356. Grayet al (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281 533. PMID: 9677190. |