ML 228 (50 MG)
货号：
4565/50 基本售价：
13077.2 元 规格：
50 mg
产品信息
概述| 货号 | 4565/50 |
| 别名 | N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine |
性能| 供应商 | Tocris |
| 生物活性 | HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 415.49 |
| 分子式 | C27H21N5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Theriaultet al (2012) Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg.Med.Chem.Lett. 22 76. PMID: 22172704. |
