| 货号 | 4165/50 |
| 别名 | 5-[2-Ethoxy-5-[(4-ethyl-1-piperazin |
| 供应商 | Tocris |
| 生物活性 | Potent PDE5 inhibitor (IC50 = 1.23 nM). Shows >100-fold selectivity for PDE5 over PDE6. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 677.79 |
| 分子式 | C23H33N7O5 |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 100 mM in DMSO |
| 参考文献 | Rawsonet al (2012) The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics. Bioorg.Med.Chem. 20 498. PMID: 22100260. Hashim and Abrams (2010) Emerging drugs for the treatment of benign prostatic obstruction. Exp.Opin.Invest.Drugs 15 159. PMID: 20446824. |