| 货号 | 3872/50 |
| 别名 | 5-(5-(7-(Trifluoromethyl)quinolin-4 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (KD values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β-amyloid peptide production in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 581.47 |
| 分子式 | C25H27F3N2O4S.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 75 mM in DMSO |
| CAS号 | 754240-09-0 |
| 参考文献 | Onestoet al (2008) Characterization of EHT1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol. 439 111. PMID: 18374160. Shuteset al (2007) Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of rac family small GTPases. J.Biol.Chem. 282 35666. PMID: 17932039. Desireet al (2005) RAC1 inhibition targets amyloid precursor protein processing by γ-secretase and decreases Aβ production in vitroandin vivo. J.Biol.Chem. 280 37516. PMID: 16150730. |