| 货号 | 4149/50 |
| 别名 | 1-[3-[(1-Methylethyl)amino]-2-pyrid |
| 供应商 | Tocris |
| 生物活性 | Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 552.67 |
| 分子式 | C22H28N6O3 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO |
| 参考文献 | Pagano and Chong (1995) In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavirdine (U-90152) with protease inhibitor U-75875 or interferon-alpha. J.Infect.Dis. 171 61. PMID: 7528253. Duewekeet al (1993) U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob.Agents Chemother. 37 1127. PMID: 7685995. |