| 货号 | 3812/50 |
| 别名 | (4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorop |
| 供应商 | Tocris |
| 生物活性 | Potent steroidal androgen receptor agonist (IC50 = 12 nM). Mimics the action of 5α-dihydrotestosterone (DHT). Transactivates the mouse mammary tumor virus (MMTV) promoter; represses MMP1 promoter activity. Inhibits 5α-reductase type I and II (IC50 values are 6 and 10 nM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 441.01 |
| 分子式 | C26H33ClN2O2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 10 mM in ethanol |
| 参考文献 | Schmidtet al (2009) Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 284 36367. PMID: 19846549. Tolmanet al (1997) 4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]. J.Steroid.Biochem.Mol.Biol. 60 303. PMID: 9219921. |