Kigamicin C
货号：
19445-2.5mg 基本售价：
13076.0 元 规格：
2.5 mg
产品信息
概述| 货号 | 19445-2.5mg |
| 描述 | Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions.1 They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media.1 A related compound, kigamicin D, is active in vivo, suppressing the tumor growth of several pancreatic cancer cell lines in nude mice.2 It blocks the activation of Akt induced in PANC-1 cells placed in nutrient-deprived media.2 Kigamicin can also induce necrosis in human myeloma cells, but not normal lymphocytes, maintained in nutrient-rich media (CC50 = 100 nM).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kunimoto, S.,Lu, J.,Esumi, H., et al. Kigamicins, novel antitumor antibiotics. I. Taxonomy, isolation, physico-chemical properties and biological activities. J.Antibiot.(Tokyo) 56(12), 1004-1011 (2003).
2.Lu, J.,Kunimoto, S.,Yamazaki, Y., et al. Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells tolerance to nutrient starvation. Cancer Science 95(6), 547-552 (2004).
3.Nakamura, M.,Esumi, H.,Jin, L., et al. Induction of necrosis in human myeloma cells by kigamicin. Anticancer Research 28(1A), 37-44 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 809.8 |
| 分子式 | C41H47NO16 |
| CAS号 | 680571-51-1 |
| 稳定性 | ≥ 2 years |
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