Pirinixic Acid Aminothiazole
货号：
15483-25mg 基本售价：
13006.0 元 规格：
25 mg
产品信息
概述| 货号 | 15483-25mg |
| 描述 | Microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) are key enzymes in the synthesis of PGE2 (Item No. 14010) and leukotrienes (LTs), respectively. PGE2 and LTs are bioactive lipids that contribute to a broad range of pathologies, including inflammation and various forms of cancer.1,2 Pirinixic acid aminothiazole is a dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM, respectively).3 It is a weak inhibitor of COX-1 and -2 and has no effect on 12- and 15-LO isoforms.3 Pirinixic acid aminothiazole reduces the synthesis of PGE2 and LTC4 (Item No. 20210) during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Funk, C.D. Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science 294, 1871-1875 (2001).
2.Samuelsson, B.,Morgenstern, R. and Jakobsson, P.J. Membrane prostaglandin E synthase -1: A novel therapeutic target. Pharmacological Reviews 59(3), 207-224 (2007).
3.Hanke, T.,Dehm, F.,Liening, S., et al. Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo. Journal of Medicinal Chemistry 56(22), 9031-9044 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 513.1 |
| 分子式 | C25H25ClN4O2S |
| CAS号 | 1492060-44-2 |
| 稳定性 | ≥ 2 years |
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