Eicosapentaenoyl Serotonin
货号：
9000640-25mg 基本售价：
12992.0 元 规格：
25 mg
产品信息
概述| 货号 | 9000640-25mg |
| 描述 | Eicosapentaenoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin (Item No. 70665). Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain.1,2 The effects of replacing the arachidonoyl portion with eicosapentaenoic acid have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50 = 0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamide (IC50 > 50 μM).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ortar, G.,Cascio, M.G.,De Petrocellis, L., et al. New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. Journal of Medicinal Chemistry 50, 6554-6569 (2007).
2.Maione, S.,De Petrocellis, L.,de Novellis, V., et al. Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. British Journal of Pharmacology 150, 766-781 (2007).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 460.7 |
| 分子式 | C30H40N2O2 |
| CAS号 | 199875-71-3 |
| 稳定性 | ≥ 1 year |
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