| 货号 | 18500-10mg |
| 描述 | Prostaglandin J2(PGJ2) is formed from PGD2 by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin.1PGJ2 inhibits platelet aggregation with an IC50 of about 5-10 nM.2,3PGJ2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.4 However, this activity has been attributed to further metabolites of PGJ2 and not the parent compound itself. |
| 别名 | PGJ2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fitzpatrick, F.A., and Wynalda, M.A. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. The Journal of Biological Chemisty 258, 11713-11718 (1983). 2.Bundy, G.L.,Morton, D.R.,Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. Journal of Medicinal Chemistry 26, 790-799 (1983). 3.Mahmud, I.,Smith, D.L.,Whyte, M.A., et al. On the identification and biological properties of prostaglandin J2. Prostaglandins, Leukotrienes and Medicine 16, 131-146 (1984). 4.Fukushima, M. Prostaglandin J2 - antitumor and anti-viral activities and the mechanisms involved. Eicosanoids 3, 189-199 (1990). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 334.5 |
| 分子式 | C20H30O4 |
| CAS号 | 60203-57-8 |
| 稳定性 | ≥ 1 year |
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