GSK923295
货号：
18389-50mg 基本售价：
12740.0 元 规格：
50 mg
产品信息
概述| 货号 | 18389-50mg |
| 描述 | GSK923295 is a potent inhibitor of centromere-associated protein E (CENP-E; Ki = 3.2 nM), a kinesin motor protein involved in mitotic checkpoint signaling.1,2 GSK923295 causes mitotic cell cycle delay, leading to apoptosis in various cancer cell lines.1 It induces apoptosis in cancer cells in mice bearing xenografts of COLO 205 cells.1,2 GSK923295 can be used with AZ3146, an inhibitor of the spindle checkpoint kinase Mps1, to generate aneuploidy in cells.3 |
| 别名 | GSK923295A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wood, K.W.,Lad, L.,Luo, L., et al. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc.Nat.Acad.Sci.USA 107(13), 5839-5844 (2010).
2.Qian, X.,McDonald, A.,Zhou, H.-J., et al. Discovery of the first potent and selective inhibitor of centromere-associated protein E: GSK923295. ACS Med.Chem.Lett 1(1), 30-34 (2010).
3.Bennett, A.,Bechi, B.,Tighe, A., et al. Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy. Oncotarget 6(25), 20921-20932 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 592.1 |
| 分子式 | C32H38ClN5O4 |
| CAS号 | 1088965-37-0 |
| 稳定性 | ≥ 2 years |
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