Toceranib
货号：
17714-50mg 基本售价：
12740.0 元 规格：
50 mg
产品信息
概述| 货号 | 17714-50mg |
| 描述 | Toceranib is a small molecule, multi-targeted receptor tyrosine kinase inhibitor that is structurally related to sunitinib (Item No. 13159).1 It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit.1 Moveover, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death.1 It is active in vivo and is commonly used against solid tumors in dogs.2,3 |
| 别名 | PHA 291639;SU11654; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liao, A.T.,Chien, M.B.,Shenoy, N., et al. Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood 100(2), 585-593 (2002).
2.London, C.,Mathie, T.,Stingle, N., et al. Preliminary evidence for biologic activity of toceranib phosphate (Palladiar) in solid tumours. Vet.Comp.Oncol. 10(3), 194-205 (2012).
3.Ranieri, G.,Gadaleta, C.D.,Patruno, R., et al. A model of study for human cancer: Spontaneous occurring tumors in dogs. Biological features and translation for new anticancer therapies. Critical Reviews in Oncology/Hematology 88, 187-197 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 396.5 |
| 分子式 | C22H25FN4O2 |
| CAS号 | 356068-94-5 |
| 稳定性 | ≥ 2 years |
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