NBD-FTY720 phenoxy (hydrochloride)
货号：
16841-5mg 基本售价：
12740.0 元 规格：
5 mg
产品信息
概述| 货号 | 16841-5mg |
| 描述 | FTY720 is an immune modulator that down-regulates sphingosine-1-phosphate (S1P) receptors,1 enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc1,2 and inhibits cytosolic phospholipase A2activity.3 It is known that some of the effects of FTY720 require its phosphorylation by sphingosine kinases in vivo, with FTY720-phosphate binding to and down-regulating S1P receptors. NBD-FTY720 is a fluorescently-labeled analog of FTY720. The hydroxy methyl side chain of FTY720 that is targeted for phosphorylation by sphingosine kinases is retained in this analog, suggesting that it would likewise be phosphorylated in vivo. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Brinkmann, V.,Davis, M.D.,Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. The Journal of Biological Chemisty 277(24), 21453-21457 (2002).
2.Honig, S.M.,Fu, S.,Mao, X., et al. FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. Journal of Clinical Investigation 111(5), 627-637 (2003).
3.Payne, S.G.,Oskeritizian, C.A.,Griffiths, R., et al. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood 109(3), 1077-1085 (2007).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥96% |
| 计算分子量 | 510 |
| 分子式 | C23H31N5O6 • HCl |
| 稳定性 | ≥ 1 year |
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