GANT 61
货号：
13841-100mg 基本售价：
12740.0 元 规格：
100 mg
产品信息
概述| 货号 | 13841-100mg |
| 描述 | Hedgehog proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the GLI family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the GLI proteins are named. GANT 61 is a GLI antagonist, inhibiting GLI1 activation of gene expression with an IC50 value of 5 μM.1 It does not affect signaling through NF-κB, glucocorticoid receptor, MAPK, HGF, C/EBPα, or HIF-1, supporting specificity for the Hedgehog pathway.1 GANT 61 has been shown to inhibit the in vitro proliferation of PANC-1 and 22Rv1 cancer cells, which have elevated GLI1 levels, and prevent the development of 22Rv1 tumors in mice.1 |
| 别名 | NSC 136476; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lauth, M.,Bergström, Å.,Shimokawa, T., et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proceedings of the National Academy of Sciences of the United States of America 104(20), 8455-8460 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 429.6 |
| 分子式 | C27H35N5 |
| CAS号 | 500579-04-4 |
| 稳定性 | ≥ 2 years |
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