| 货号 | 13357-100mg |
| 描述 | Phosphodiesterase 3 (PDE3) family members have high-affinities for both cAMP and cGMP and show cGMP-dependent inhibition of cAMP hydrolysis. Milrinone is a potent inhibitor of type 3 phosphodiesterases (PDEs), inhibiting recombinant PDE3A and PDE3B with IC50 values of 0.45 and 1.0 μM, respectively.1 It less effectively inhibits other PDE isoforms, with IC50 values of 263, >300, 17.5, 49.1, and 58.3 μM for PDE1, PDE2, PDE4, PDE5, and PDE7, respectively.1 Milrinone has positive inotropic (stimulates cardiac muscle contractions) and vasodilatory effects when administered in vivo.2,3,4 |
| 别名 | Primacor®;WIN 47,203; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sudo, T.,Tachibana, K.,Toga, K., et al. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phophodiesterase isozyme activity. Biochemical Pharmacology 59, 347-356 (2000). 2.Lakshminrusimha, S.,Porta, N.F.M.,Farrow, K.N., et al. Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn. Pediatr.Crit.Care Med. 10(1), 106-112 (2009). 3.Simkova, V.,Radermacher, P., and Barth, E. Metabolic effects of phophodiesterase III inhibitors: Another reason to promote their use? Critical Care 11(3), (2007). 4.Maskin, C.S.,Sinoway, L.,Chadwick, B., et al. Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart failure. Circulation Journal 67, 1065-1070 (1983). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 211.2 |
| 分子式 | C12H9N3O |
| CAS号 | 78415-72-2 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |