| 货号 | 10008612-5mg |
| 描述 | FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1 FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5).2 Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.3 azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brinkmann, V.,Pinschewer, D.D.,Feng, L., et al. FTY720: Altered lymphocyte traffic results in allograft protection. Transplantation 72, 764-769 (2001). 2.Brinkmann, V.,Davis, M.D.,Heise, C.E., et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. The Journal of Biological Chemisty 277(24), 21453-21457 (2002). 3.Matloubian, M.,Lo, C.G.,Cinamon, G., et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355-360 (2004). 4.Sun, C., and Bittman, R. A photoreactive analogue of the immunosuppressant FTY720. The Journal of Organic Chemistry 71, 2200-2202 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348.5 |
| 分子式 | C19H32N4O2 |
| CAS号 | 881914-35-8 |
| 稳定性 | ≥ 2 years |
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