| 货号 | 3915/50 |
| 别名 | 5-(2,6-Dichlorophenyl)-2-[2,4-diflu |
| 供应商 | Tocris |
| 生物活性 | Highly potent and selective p38α inhibitor (IC50 = 10 nM). Also blocks TNFα production in LPS-stimulated HWB in vitro(IC50 = 177 nM). Displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and JNK1-3. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 436.26 |
| 分子式 | C19H9Cl2F2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Duffyet al (2011) The discovery of VX-745: a novel and selective p38α kinase inhibitor. ACS Med.Chem.Lett. 2758. Goldsteinet al (2010) Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J.Med.Chem. 53 2345. PMID: 19950901. Bagleyet al (2007) Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. Bioorg.Med.Chem.Lett. 17 5107. PMID: 17659871. |