| 货号 | 3575/50 |
| 别名 | N-[(1S)-2-[4-(5-Chloro-2,3-dihydro- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective phospholipase D1 (PLD1) inhibitor (IC50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 499.43 |
| 分子式 | C26H27CIN4O2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| CAS号 | 1130067-06-9 |
| 参考文献 | Lewiset al (2009) Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg.Med.Chem.Lett. 19 1916. PMID: 19268584. Scottet al (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat.Chem.Biol. 5 108. PMID: 19136975. |