| 货号 | 5286/50 |
| 别名 | N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of Aurora kinase A (IC50 = 3.4 nM); exhibits 1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC50 values are 0.19 and 2.9 μM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 588.07 |
| 分子式 | C31H31ClFN7O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Yuanet al (2012) Overcoming CML acquired resistance by specific inhibition of Aurora A kinse in the KCL-22 cell model. Carcinogenesis 33 285. PMID: 22116466. Aliagas-Martinet al (2009) A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem. 52 3300. PMID: 19402633. |