| 货号 | 1969/50 |
| 别名 | α-[Amino[(4-aminophenyl)thio]methyle |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 335.35 |
| 分子式 | C16H12F3O3S |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 305350-87-2 |
| 参考文献 | Wanget al (2003) Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J.Pharmacol.Exp.Ther. 304 172. PMID: 12490588. Daviset al (2000) The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J.Neurosci. 20 4563. PMID: 10844026. Scherleet al (2000) Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J.Biol.Chem. 275 37086. PMID: 10969080. Atkinset al (1998) The MAPK cascade is required for mammalian associative learning. Nature Neurosci. 1602. |