| 货号 | 4928/50 |
| 别名 | 3-(3,5-Dimethyl-4-isoxazolyl)-5-hyd |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC50 = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Reduces viability of lung adenocarcinoma cell lines and attenuates proliferation of MV-4-11 leukemia cells. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 295.33 |
| 分子式 | C18H17NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming |
| 参考文献 | Hewingset al (2013) Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem. 56 3217. PMID: 23517011. Hewingset al (2011) 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J.Med.Chem. 54 6761. PMID: 21851057. |