| 货号 | 1391/50 |
| 别名 | 4,4',4'',4'''-[Carbonylbis(imino-5,1,3-be |
| 供应商 | Tocris |
| 生物活性 | Potent purinergic receptor antagonist that displays high selectivity for P2X1(IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Provides antithrombotic protection in vivo. Also acts as a Gsα-selective antagonist. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 1505.06 |
| 分子式 | C41H24N6Na8O29S8 |
| 可溶性/溶解性 | Soluble to 50 mM in water with gentle warming |
| CAS号 | 389142-38-5 |
| 参考文献 | Fleminget al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9. PMID: 21164513. Hechleret al (2005) Inhibition of platelet functions and thrombosis through selective or non-selective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4",4'"-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt]. J.Pharmacol.Exp.Ther. 314 232. PMID: 15792995. Rettingeret al (2005) Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist. Neuropharmacology. 48 461. PMID: 15721178. Hoheneggeret al (1998) Gsα-selective G protein antagonists. Proc.Natl.Acad.Sci.U.S.A. 95 346. PMID: 9419378. |