| 货号 | 3794/50 |
| 别名 | 3,6-Dibromo-9-[2-fluoro-3-(1-pipera |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 542.11 |
| 分子式 | C19H20Br2FN3 |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO |
| 参考文献 | Peixotoet al (2009) MAC inhibitors suppress mitochondrial apoptosis. Biochem.J. 423 381. PMID: 19691447. Bombrunet al (2003) 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 4365. PMID: 14521400. |