| 货号 | 3824/50 |
| 别名 | 5-(5,6,7,8-Tetrahydro-5,5,8,8-tetra |
| 供应商 | Tocris |
| 生物活性 | Potent and selective RARβ receptor agonist (Kdvalues are 145 and >3760 nM for RARβ and RARα receptors respectively; no binding detected at RARγ). Inhibits growth of human HNSCC 22B, 183A and 22A cells (IC50 values are 3.0, 5.7 and 8.0 μM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 364.5 |
| 分子式 | C23H24O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Zhao (2009) Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. Cancer Res. 69 5218. PMID: 19470764. Sun (2000) Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells. Clin.Cancer Res. 6 1563. PMID: 10778990. Szondy (1998) Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor alpha. Biochem.J. 3 767. PMID: 9560303. |