| 货号 | 3346/50 |
| 别名 | N-[cis-4-[[4-(Dimethylamino)-2-quin |
| 供应商 | Tocris |
| 生物活性 | Potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT2B and 5-HT1A receptors (IC50 values are 9.66 and 16.9 nM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 461.94 |
| 分子式 | C23H25F2N5O.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 510733-97-8 |
| 参考文献 | Chakiet al (2005) Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 313 831. PMID: 15677346. Chakiet al (2005) ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 11 341. PMID: 16614734. |