| 货号 | 5053/50 |
| 别名 | 4-[4,4-Difluoro-1-(2-fluorophenyl)c |
| 供应商 | Tocris |
| 生物活性 | Potent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 306.32 |
| 分子式 | C18H17F3O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Georgeet al (2013) Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem.Neurosci. 4 1537. PMID: 24020966. McFarlandet al (2013) AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem.Neurosci. 4 1249. PMID: 23898966. |