| 货号 | 18770-2.5mg |
| 描述 | Thielavin B is a fungal metabolite that contains O-substituted salicylic acid.1 It inhibits cyclooxygenase, blocking both the conversion of arachidonic acid (Item No. 90010) to Prostaglandin H2(PGH2) (Item No. 17020) and the conversion of PGH2 to PGE2 (Item No. 14010, IC50s = 40 and 9 µM, respectively).2 Thielavin B also inhibits the reverse transcriptase of avian myeloblastosis virus, bacterial transglycosylases, and telomerase activity.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kitahara, N.,Haruyama, H.,Hata, T., et al. The structures of thielavins A, B and C. Prostaglandin synthetase inhibitors from fungi. J.Antibiot.(Toyko) 36(5), 599-600 (1983). 2.Kitahara, N.,Endo, A.,Furuya, K., et al. Thielavin A and B, new inhibitors of prostaglandin biosynthesis produced by Thielavia terricola. J.Antibiot.(Toyko) 34(12), 1562-1568 (1981). 3.Take, Y.,Inouye, Y., and Nakamura, S. Comparative studies of the inhibitory properties of antibiotics on human immunodeficiency virus and avian myeloblastosis virus reverse transcriptases and cellular DNA polymerases. Journal of Antibiotics XLII(1), 107-115 (1989). 4.Mani, N.,Sancheti, P.,Jiang, Z.D., et al. Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus. J.Antibiot.(Toyko) 51(5), 471-479 (1998). 5.Togashi, K.i.,Ko, H.R.,Ahn, J.S., et al. Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B. Bioscience, Biotechnology, and Biochemistry 65(3), 651-653 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 566.6 |
| 分子式 | C31H34O10 |
| CAS号 | 71950-67-9 |
| 稳定性 | ≥ 2 years |
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