| 货号 | 11637-250mg |
| 描述 | Docetaxel is a semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM).1 It has proven more effective than taxol in preventing the proliferation of cancer cells.1,2 Docetaxel has applications in breast cancer and hormone-refractory prostate cancer.3,4 This product is intended for research applications. |
| 别名 | NSC 628503;RP 56976;Taxotel; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bissery, M.C.,Guenard, D.,Gueritte-Voegelein, F., et al. Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue. Cancer Research 51, 4845-4852 (1991). 2.Pazdur, R.,Kudelka, A.P.,Kavanagh, J.J., et al. The taxoids: Paclitaxel (Taxolr) and docetaxel (Taxoterer). Cancer Treatment Reviews 19, 351-386 (1993). 3.Mahon, K.L.,Henshall, S.M.,Sutherland, R.L., et al. Pathways of chemotherapy resistance in castration-resistant prostate cancer. Endocrine-Related Cancer 18, R103-R123 (2011). 4.Yao, X.,Hosenpud, J.,Chitambar, C.R., et al. A phase II study of concurrent docetaxel, epirubicin and cyclophospha-mide as a neoadjuvant chemotherapy regimen in patients with locally advanced breast cancer. Journal of Cancer 3, 145-151 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 807.9 |
| 分子式 | C43H53NO14 |
| CAS号 | 114977-28-5 |
| 稳定性 | ≥ 2 years |
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