LBQ657
货号：
19829-25mg 基本售价：
12516.0 元 规格：
25 mg
产品信息
概述| 货号 | 19829-25mg |
| 描述 | LBQ657 is an inhibitor of neprilysin, a zinc metallopeptidase that degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1.1 Inhibition of neprilysin leads to an increased level of these peptides and, thus, antihypertensive effects. LBQ657 can be produced in vivo via the metabolism of the prodrug sacubitril. Sacubitril has been combined with the angiotensin receptor blocker valsartan (Item No. 14178) in the clinical treatment of hypertension and heart failure.2 |
| 别名 | Sacubitrilat; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schiering, N.,DArcy, A.,Villard, F., et al. Structure of neprilysin in complex with the active metabolite of sacubitril. Sci.Rep. 6:27909, (2016).
2.Gu, J.,Noe, A.,Chandra, P., et al. Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi). J.Clin.Pharmacol. 50(4), 401-414 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 383.4 |
| 分子式 | C22H25NO5 |
| CAS号 | 149709-44-4 |
| 稳定性 | ≥ 2 years |
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