| 货号 | 18444-5mg |
| 描述 | Luzopeptin A is a cyclic depsipeptide antibiotic first isolated from an actinomycete strain.1,2 It displays antitumor activity, as it is highly active in mice against a variety of experimental tumors.1 Luzopeptin A acts as a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules.3 It also inhibits reverse transcriptases from HIV-1 and HIV-2 (IC50s = 7 and 68 nM, respectively), as well as cellular DNA polymerases.4,5 |
| 别名 | BBM-928A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ohkuma, H.,Sakai, F.,Nishiyama, Y., et al. BBM-928, a new antitumor antibiotic complex. I. Productiom, isolation, characterization and antitumor activity. Journal of Antibiotics XXXIII(10), 1087-1097 (1980). 2.Konishi, M.,Ohkuma, H.,Sakai, F., et al. BBM-928, a new antitumor antibiotic complex. III. Structure determination of BBM-928 A, B and C. Journal of Antibiotics XXXIV(2), 148-159 (1981). 3.Huang, C.H.,Mirabelli, C.K.,Mong, S., et al. Intermolecular cross-linking of DNA through bifunctional intercalation of an antitumor antibiotic, luzopeptin A (BBM-928A). Cancer Research 43, 2718-2724 (1983). 4.Lingham, R.B.,Hsu, A.H.M.,OBrien, J.A., et al. Quinoxapeptins: A novel chromodepsipeptide inhibitors of HIV-1 and HIV-2 reverse transcriptase I. The producing organism and biological activity. Journal of Antibiotics 49(3), 254-259 (1996). 5.Take, Y.,Inouye, Y., and Nakamura, S. Comparative studies of the inhibitory properties of antibiotics on human immunodeficiency virus and avian myeloblastosis virus reverse transcriptases and cellular DNA polymerases. Journal of Antibiotics XLII(1), 107-115 (1989). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 1427.4 |
| 分子式 | C64H78N14O24 |
| CAS号 | 75580-37-9 |
| 稳定性 | ≥ 2 years |
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