Ophiobolin B
货号：
18432-5mg 基本售价：
12516.0 元 规格：
5 mg
产品信息
概述| 货号 | 18432-5mg |
| 描述 | Calmodulin is a calcium-sensing protein that regulates a wide array of proteins involved in diverse cellular functions. Ophiobolin B is a sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, producing cytotoxic and antimicrobial effects. It induces apoptosis in chronic lymphocytic leukemia cells with an LC50 value of 2 nM and in different zygomycetes with MIC values ranging from 25-50 µg/ml.1,2 |
| 别名 | Cochliobolin B;Ophiobolsin A;Zizanin B; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bladt, T.T.,Dürr, C.,Knudsen, P.B., et al. Bio-activity and dereplication-based discovery of ophiobolins and other fungal secondary metabolites targeting leukemia cells. Molecules 18(12), 14629-14650 (2013).
2.Krizsán, K.,Bencsik, O.,Nyilasi, I., et al. Effect of the sesterterpene-type metabolites, ophiobolins A and B, on zygomycetes fungi. FEMS Microbiology Letters 313(2), 135-140 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 402.6 |
| 分子式 | C25H38O4 |
| CAS号 | 5601-74-1 |
| 稳定性 | ≥ 2 years |
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