| 货号 | 13300-25mg |
| 描述 | Bisindolylmaleimide V (BIM V) is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 µM.1,2,3 While effectively inactive as a PKC inhibitor, BIM V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 µM.4 |
| 别名 | BIM V;Ro 31-6045; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lazareno, S.,Popham, A. and Birdsall, N.J.M. Muscarinic interactions of bisindolylmaleimide analogues. European Journal of Pharmacology 360, 281-284 (1998). 2.Toullec, D.,Pianetti, P.,Coste, H., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. The Journal of Biological Chemisty 266(24), 15771-15781 (1991). 3.Davis, P.D.,Hill, C.H.,Lawton, G., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides. Journal of Medicinal Chemistry 35, 177-184 (1992). 4.Marmy-Conus, N.,Hannan, K.M. and Pearson, R.B. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70s6k/p85s6k : Implications for the analysis of S6K signalling. FEBS Letters 519, 135-140 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 341.3 |
| 分子式 | C21H15N3O2 |
| CAS号 | 113963-68-1 |
| 稳定性 | ≥ 2 years |
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