JGB1741
货号：
10641-25mg 基本售价：
12502.0 元 规格：
25 mg
产品信息
概述| 货号 | 10641-25mg |
| 描述 | The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to longevity, cancer, gene regulation, energy homeostasis, and apoptosis.1,2 JGB1741 is a small molecule inhibitor of SIRT1 with an IC50 value of 15 μM in a cell-free assay.3 It shows relatively weak inhibition for SIRT2 and SIRT3 with IC50 values greater than 100 μM. JGB1741 inhibits metastatic breast cancer MDA-MB 231 cell proliferation with an IC50 value of 512 nM in a cell-based assay and dose-dependently increases p53 acetylation and p53-mediated apoptosis in these cells. |
| 别名 | ILS-JGB-1741; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yamamoto, H.,Schoonjans, K., and Auwerx, J. Sirtuin functions in health and disease. Molecular Endocrinology 21(8), 1745-1755 (2007).
2.Milne, J.C., and Denu, J.M. The sirtuin family:Therapeutic targets to treat diseases of aging. Current Opinion in Chemical Biology 12, 11-17 (2008).
3.Kalle, A.M.,Mallika, A.,Badiger, J., et al. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochemical and Biophysical Research Communications 401, 13-19 (2010).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 440.6 |
| 分子式 | C27H24N2O2S |
| CAS号 | 1256375-38-8 |
| 稳定性 | ≥ 1 year |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
