BAY 41-8543
货号：
10011131-25mg 基本售价：
12502.0 元 规格：
25 mg
产品信息
概述| 货号 | 10011131-25mg |
| 描述 | Soluble guanylate cyclase (sGC) is the primary cellular receptor for nitric oxide (NO). NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cyclic GMP (cGMP). BAY 41-8543 is a heme-dependent stimulator of sGC, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold.1 Surprisingly, NO donors synergize with BAY 41-8543 in stimulating recombinant sGC.1 BAY 41-8543 relaxes vessels and inhibits platelet aggregation in vitro at nM concentrations.1In vivo, BAY 41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis.2 Inhalation of microparticles containing BAY 41-8543 increases pulmonary vasodilation without changing mean arterial pressure,3 suggesting that agonists of sGC may be efficacious in treating pulmonary hypertension. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Stasch, J.P.,Alonso-Alija, C.,Apeler, H., et al. Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: In vitro studies. British Journal of Pharmacology 135, 333-343 (2002).
2.Stasch, J.P.,Dembowsky, K.,Perzborn, E., et al. Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies. British Journal of Pharmacology 135, 344-355 (2002).
3.Evgenov, O.V.,Kohane, D.S.,Bloch, K.D., et al. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. American Journal of Respiration and Critical Care Medicine 176, 1138-1145 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 420.4 |
| 分子式 | C21H21FN8O |
| CAS号 | 256498-66-5 |
| 稳定性 | ≥ 2 years |
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