MIV-150
货号：
9002360-10mg 基本售价：
12460.0 元 规格：
10 mg
产品信息
概述| 货号 | 9002360-10mg |
| 描述 | MIV-150 is a tight-binding, allosteric inhibitor of reverse transcriptase that is active against HIV-1 and HIV-2 (both EC50s = 1 nM in vitro).1 It has been shown to inactivate viruses that are resistant to other antiviral drugs, including non-nucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors, and protease inhibitors.1 Although MIV-150 possesses poor oral bioavailability, it demonstrates efficacy when formulated as a topical microbicide.2,3 |
| 别名 | PC-815; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fernández-Romero, J.A.,Thorn, M.,Turville, S.G., et al. Carrageenan/MIV-150 (PC-815), a combination microbicide. Sex.Transm.Dis. 34(1), 9-14 (2007).
2.Turville, S.G.,Aravantinou, M.,Miller, T., et al. Efficacy of Carraguardr-based microbicides in vivo despite variable in vitro activity. PLoS One 3(9), e3162 (2008).
3.Singer, R.,Derby, N.,Rodriguez, A., et al. The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques. Journal of Virology 85(11), 5504-5512 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 368.4 |
| 分子式 | C19H17FN4O3 |
| CAS号 | 231957-54-3 |
| 稳定性 | ≥ 2 years |
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